Islet amyloid in recent-onset type 1 diabetes—the DiViD study

Type 1 diabetes is characterized by an immune-mediated destruction of the beta-cells, associated with autoantibodies against islet antigens developing years ahead of the clinical manifestation. However, the disease is heterogeneous, and its pathogenesis is far from fully understood. Besides focus on the importance of virus, hygiene, early nutrition, gut microbiome, etc., one hypothesis is that factors leading to beta-cell stress, usually associated with type 2 diabetes, also might contribute to development of type 1 diabetes (1). Islet amyloid is to a varying degree present in almost all individuals with type 2 diabetes, and the beta-cell product islet amyloid polypeptide (IAPP) is the primary constituent of the islet amyloid. IAPP is a member of the calcitonin gene